RESUMO
Abstract Toxoplasmic retinochoroiditis (TR) is the most common identifiable cause of posterior uveitis in Brazil. Response to treatment and clinical presentation may vary significantly. We assessed serum levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), neurotrophin (NT)-3, and NT-4/5 in patients with active TR, before and after TR treatment. Methods: Twenty patients with active lesion and 15 healthy controls were enrolled in the study. Serum concentration of neurotrophic factors was determined by enzyme-linked immunosorbent assay. Results: BDNF levels were significantly higher in patients before treatment when compared with controls (p = 0.0015). There was no significant difference in pro-BDNF, NGF, GDNF, NT-3, and NT-4/5 levels between TR patients and controls. Treatment did not affect the levels of these factors. Conclusion: BDNF may be released in the context of the active TR inflammatory response.
Assuntos
Humanos , Masculino , Feminino , Adulto , Biomarcadores/sangue , Toxoplasmose Ocular/sangue , Coriorretinite/sangue , Ensaio de Imunoadsorção Enzimática , Estudos de Casos e Controles , Coriorretinite/parasitologia , Fator Neurotrófico Derivado do Encéfalo/sangue , Fator de Crescimento Neural/sangue , Neurotrofina 3/sangue , Fator Neurotrófico Derivado de Linhagem de Célula Glial/sangue , Fatores de Crescimento Neural/sangueRESUMO
Toxoplasmic retinochoroiditis (TR) is the most common identifiable cause of posterior uveitis in Brazil. Response to treatment and clinical presentation may vary significantly. We assessed serum levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), neurotrophin (NT)-3, and NT-4/5 in patients with active TR, before and after TR treatment. METHODS: Twenty patients with active lesion and 15 healthy controls were enrolled in the study. Serum concentration of neurotrophic factors was determined by enzyme-linked immunosorbent assay. RESULTS: BDNF levels were significantly higher in patients before treatment when compared with controls (p=0.0015). There was no significant difference in pro-BDNF, NGF, GDNF, NT-3, and NT-4/5 levels between TR patients and controls. Treatment did not affect the levels of these factors. CONCLUSION: BDNF may be released in the context of the active TR inflammatory response.
Assuntos
Biomarcadores/sangue , Coriorretinite/sangue , Toxoplasmose Ocular/sangue , Adulto , Fator Neurotrófico Derivado do Encéfalo/sangue , Estudos de Casos e Controles , Coriorretinite/parasitologia , Ensaio de Imunoadsorção Enzimática , Feminino , Fator Neurotrófico Derivado de Linhagem de Célula Glial/sangue , Humanos , Masculino , Fator de Crescimento Neural/sangue , Fatores de Crescimento Neural/sangue , Neurotrofina 3/sangueRESUMO
Hereditary spastic paraplegia (HSP) is characterized by weakness and spasticity of the lower extremities. Kjellin's syndrome is a rare syndrome associated with HSP. The syndrome is characterized by the presence of bilateral retinal flecks, similar to the findings in Stargardt disease and fundus flavimaculatus. We report the case of a 34-year-old male who presented with complete features of Kjellin's syndrome, with typical retinal findings observed on multimodal imaging (spectral domain optical coherence tomography [SD-OCT], near-infrared reflectance and autofluorescence imaging). The ophthalmological changes at early stages of the disease may not impair visual acuity. Therefore, the detection of central retinal degeneration requires thorough fundus examination.
Assuntos
Degeneração Macular/complicações , Degeneração Retiniana/complicações , Paraplegia Espástica Hereditária/complicações , Adulto , Eletrorretinografia/métodos , Angiofluoresceinografia/métodos , Humanos , Degeneração Macular/diagnóstico , Degeneração Macular/fisiopatologia , Masculino , Degeneração Retiniana/diagnóstico , Degeneração Retiniana/fisiopatologia , Paraplegia Espástica Hereditária/diagnóstico , Paraplegia Espástica Hereditária/fisiopatologia , Espectroscopia de Luz Próxima ao Infravermelho/métodos , Tomografia de Coerência Óptica/métodos , Acuidade VisualRESUMO
Hereditary spastic paraplegia (HSP) is characterized by weakness and spasticity of the lower extremities. Kjellin’s syndrome is a rare syndrome associated with HSP. The syndrome is characterized by the presence of bilateral retinal flecks, similar to the findings in Stargardt disease and fundus flavimaculatus. We report the case of a 34-year-old male who presented with complete features of Kjellin’s syndrome, with typical retinal findings observed on multimodal imaging (spectral domain optical coherence tomography [SD-OCT], near-infrared reflectance and autofluorescence imaging). The ophthalmological changes at early stages of the disease may not impair visual acuity. Therefore, the detection of central retinal degeneration requires thorough fundus examination.
A paralisia espástica hereditária (HSP) é caracterizada por fraqueza e espasticidade das extremidades inferiores. A síndrome de Kjellin é uma rara associação de HSP com a presença de flecks retinianos similares aos encontrados em pacientes com doença de Stargardt ou fundus flavimaculatus. Descrevemos os achados em imagens multimodais da retina (tomografia de coerência óptica de domínio espectral [SD-OCT], reflectância próxima ao infravermelho e autofluorescência) em um paciente de 34 anos que apresenta conjunto completo de sinais e sintomas da síndrome de Kjellin. As alterações retinianas em estágios iniciais da doença podem aparecer, mesmo sem redução da acuidade visual, e por isso, para detecção da degeneração central da retina, é necessário exame minucioso do fundo de olho.
Assuntos
Idoso , Humanos , Antibacterianos/uso terapêutico , Artroplastia de Quadril/economia , Artroplastia do Joelho/economia , Mupirocina/uso terapêutico , Infecções Estafilocócicas/prevenção & controle , Infecção da Ferida Cirúrgica/prevenção & controle , Administração Intranasal , Antibacterianos/economia , Análise Custo-Benefício , Técnicas de Apoio para a Decisão , Árvores de Decisões , Custos de Cuidados de Saúde , Controle de Infecções/economia , Controle de Infecções/métodos , Mupirocina/economia , Cuidados Pré-Operatórios , Anos de Vida Ajustados por Qualidade de Vida , Staphylococcus aureus , Infecções Estafilocócicas/diagnóstico , Infecções Estafilocócicas/economia , Infecção da Ferida Cirúrgica/economia , Estados UnidosRESUMO
BACKGROUND: This paper reports the case of a pleomorphic manifestation of syphilis, a reemerging sexually transmitted disease. FINDINGS: A 51-year-old male presented with bilateral nongranulomatous anterior uveitis associated with an isolated syphilitic chancre of the tongue that was successfully treated with parenteral benzathine penicillin. CONCLUSION: Syphilis has the potential to lead to any type of intraocular inflammation. A careful review of the symptoms is useful for the detection of extraocular signs of syphilitic infection.
